Files used to generate the data for figures in: Rastetter, EB, Kwiatkowski, BL. An approach to modeling resource optimization for substitutable and interdependent resources. Ecological Modelling (2020). https://doi.org/10.1016/j.ecolmodel.2020.109033. This paper presents a hierarchical approach to modeling organism acclimation to changing availability of and requirements for substitutable and interdependent resources. Substitutable resources are resources that fill the same metabolic or stoichiometric need of the organism. Interdependent resources are resources whose acquisition or expenditure are tightly linked (e.g., light, carbon dioxide, and water in photosynthesis and associated transpiration). We illustrate the approach by simulating the development of vegetation with four substitutable sources of nitrogen that differ only in the cost of their uptake and assimilation.